Induction of microsomal enzymes by this drug, may well shorten the 50 percent-life of doxycycline for as long as 2 weeks following barbiturate therapy discontinued; monitor scientific reaction to doxycycline closely if equally drugs administered concurrently

pentobarbital will lower the extent or result of estrogens esterified by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.

pentobarbital will lower the level or result of clarithromycin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unknown.

pentobarbital will raise the level or impact of ivosidenib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of ivosidenib with robust CYP3A4 inducers decreased ivosidenib plasma concentrations.

pentobarbital will lessen the extent or influence of levoketoconazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unidentified.

pentobarbital will increase toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. CYP3A4 inducers may perhaps enhance the metabolism of ifosfamide to its Energetic alkylating metabolites.

pentobarbital will lessen the level or impact of amlodipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.

pentobarbital will lower the extent or effect of methadone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.

pentobarbital will lower the extent or impact of eltrombopag by affecting hepatic enzyme CYP2C9/ten metabolism. Use Warning/Check.

pentobarbital will decrease the get more info level or result of siponimod by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of siponimod with a drug that causes average CYP2C9 in addition a average or potent CYP3A4 inducer is just not proposed.

pentobarbital will decrease the extent or influence of atazanavir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unfamiliar.

pentobarbital will lessen the level or result of norgestrel by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Reasonable CYP3A4 inducers may perhaps reduce progestin focus; consider utilization of more barrier techniques

pentobarbital will lessen the level or result of propafenone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Not known.

Comment: Barbiturates might enhance adverse effects, such as respiratory despair, produced by poisonous doses of TCAs. With therapeutic doses of TCAs, barbiturates maximize metabolism and decrease blood concentrations of TCAs.